Compile Data Set for Download or QSAR
maximum 50k data
Found 606 of ec50 data for polymerid = 50004938
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50597919(CHEMBL5187795)
Affinity DataEC50:  0.200nMAssay Description:Inhibition of wild type HIV-1 reverse transcriptase assessed as reduction in luciferase reporter activity by single-round assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50094288(5-(2,6-Diamino-purin-9-yl)-2-ethynyl-2-hydroxymeth...)
Affinity DataEC50:  0.300nMAssay Description:Tested in vitro against HIV-1 LAI from MT-4 cells using MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM222178(Rilpivirine)
Affinity DataEC50:  0.400nMAssay Description:Inhibition of wild type HIV-1 reverse transcriptase assessed as reduction in luciferase reporter activity by single-round assayMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50032238(6-(3',5'-DIMETHYLBENZYL)-1-ETHOXYMETHYL-5-ISOPROPY...)
Affinity DataEC50:  0.600nMAssay Description:Inhibitory concentration against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataEC50:  1nMAssay Description:Antiviral activity against wild type HIV1 NL4-3 in MT4 cells by MTT assayMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50094288(5-(2,6-Diamino-purin-9-yl)-2-ethynyl-2-hydroxymeth...)
Affinity DataEC50:  1.30nMAssay Description:Tested in vitro against HIV-1 MDR using MAGI assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50171981(4-[2-(5-Ethyl-7,10-dimethyl-11-oxo-10,11-dihydro-5...)
Affinity DataEC50:  1.30nMAssay Description:Effective concentration towards HIV-1 wild type reverse transcriptase activity by 50% measured in cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50094282(2-Amino-9-(5-ethynyl-4-hydroxy-5-hydroxymethyl-tet...)
Affinity DataEC50:  1.40nMAssay Description:Tested in vitro against HIV-1 LAI from MT-4 cells using MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50171976(4-[2-(5-Ethyl-7-fluoro-10-methyl-11-oxo-10,11-dihy...)
Affinity DataEC50:  1.5nMAssay Description:Effective concentration towards HIV-1 wild type reverse transcriptase activity by 50% measured in cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50094286(4-Amino-1-(5-ethynyl-4-hydroxy-5-hydroxymethyl-tet...)
Affinity DataEC50:  1.5nMAssay Description:Tested in vitro against HIV-1 MDR using MAGI assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50171971(4-[2-(5-Ethyl-10-methyl-11-oxo-10,11-dihydro-5H-4,...)
Affinity DataEC50:  1.60nMAssay Description:Effective concentration towards HIV-1 wild type reverse transcriptase activity by 50% measured in cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50171982(4-[2-(7-Chloro-5-ethyl-10-methyl-11-oxo-10,11-dihy...)
Affinity DataEC50:  1.60nMAssay Description:Effective concentration towards HIV-1 wild type reverse transcriptase activity by 50% measured in cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50032235(6-(3,5-Dimethyl-benzyl)-1-ethoxymethyl-5-ethyl-1H-...)
Affinity DataEC50:  1.60nMAssay Description:Inhibitory concentration against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50171974(4-[2-(5-Ethyl-7-methoxy-10-methyl-11-oxo-10,11-dih...)
Affinity DataEC50:  1.90nMAssay Description:Effective concentration towards HIV-1 wild type reverse transcriptase activity by 50% measured in cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  2nMAssay Description:Effective concentration required to achieve 50% inhibition of HIV-1 LAI replication in human T4 lymphoblastoid CEM-SS cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM2337(6-benzyl-1-(ethoxymethyl)-5-(propan-2-yl)-1,2,3,4-...)
Affinity DataEC50:  2nMAssay Description:Effective concentration required against wild type HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50171980(3-Ethyl-4-[2-(5-ethyl-10-methyl-11-oxo-10,11-dihyd...)
Affinity DataEC50:  2.20nMAssay Description:Effective concentration towards HIV-1 wild type reverse transcriptase activity by 50% measured in cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50004148(1-Benzyloxymethyl-5-isopropyl-6-phenylsulfanyl-1H-...)
Affinity DataEC50:  2.70nMAssay Description:Inhibition of HIV-1 reverse transcriptase at 37 degree centigradeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50032236(6-(3,5-Dimethyl-benzyl)-1-(2-hydroxy-ethoxymethyl)...)
Affinity DataEC50:  2.70nMAssay Description:Inhibitory concentration against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50008329(6-(3,5-Dimethyl-phenylsulfanyl)-1-(2-hydroxy-ethox...)
Affinity DataEC50:  2.70nMAssay Description:Inhibition of HIV-1 reverse transcriptase at 37 degree centigradeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50008329(6-(3,5-Dimethyl-phenylsulfanyl)-1-(2-hydroxy-ethox...)
Affinity DataEC50:  2.70nMAssay Description:Inhibitory concentration against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50004148(1-Benzyloxymethyl-5-isopropyl-6-phenylsulfanyl-1H-...)
Affinity DataEC50:  2.70nMAssay Description:Inhibitory concentration against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  3nMAssay Description:Antiviral activity against wild type HIV1 NL4-3 in MT4 cells by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  3nMAssay Description:Effective concentration required to inhibit HIV-1 induced cytopathicity by 50% in CEM cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  3nMAssay Description:Antiviral activity against HIV1 K103N mutant in MT4 cells by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  3nMAssay Description:Antiviral activity against HIV1 Y188L mutant in MT4 cells by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  3nMAssay Description:Reverse transcriptase activity was measured in the culture supernatant, concentration that reduces by 50% the HIV produced in the supernatant.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Affinity DataEC50:  3nMAssay Description:Effective concentration in vitro agaianst HIV-1-infected CEM cells relative to uninfected untreated controlsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50407268(CHEMBL136976)
Affinity DataEC50:  3.17nMAssay Description:Effective concentration in vitro agaianst HIV-1-infected CEM cells relative to uninfected untreated controlsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50171973(3-Bromo-4-[2-(5-ethyl-10-methyl-11-oxo-10,11-dihyd...)
Affinity DataEC50:  3.20nMAssay Description:Effective concentration towards HIV-1 wild type reverse transcriptase activity by 50% measured in cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50004138(1-Benzyloxymethyl-6-(3,5-dimethyl-phenylsulfanyl)-...)
Affinity DataEC50:  3.20nMAssay Description:Inhibitory concentration against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50407265(CHEMBL334551)
Affinity DataEC50:  3.27nMAssay Description:Effective concentration in vitro agaianst HIV-1-infected CEM cells relative to uninfected untreated controlsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50171972(4-[2-(5-Ethyl-10-methyl-11-oxo-10,11-dihydro-5H-4,...)
Affinity DataEC50:  3.30nMAssay Description:Effective concentration towards HIV-1 wild type reverse transcriptase activity by 50% measured in cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50103642(4-(6-amino-5-bromo-2-(4-cyanophenylamino)pyrimidin...)
Affinity DataEC50:  3.40nMAssay Description:Inhibition of HIV-1 p66/p51 reverse transcriptase K103N mutant incubated for 40 mins by picogreen dye-based spectrofluorometric analysisMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataEC50:  4nMAssay Description:Concentration required to inhibit HIV-1 reverse transcriptase activity (wild-type) by 50%More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM2337(6-benzyl-1-(ethoxymethyl)-5-(propan-2-yl)-1,2,3,4-...)
Affinity DataEC50:  4nMAssay Description:Inhibition of HIV-1 reverse transcriptase at 37 degree centigradeMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM2337(6-benzyl-1-(ethoxymethyl)-5-(propan-2-yl)-1,2,3,4-...)
Affinity DataEC50:  4.20nMAssay Description:Inhibitory concentration against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50004127(6-(3,5-Dimethyl-phenylsulfanyl)-1-ethoxymethyl-5-e...)
Affinity DataEC50:  4.40nMAssay Description:Inhibitory concentration against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50094278(4-Amino-1-(5-ethynyl-4-hydroxy-5-hydroxymethyl-tet...)
Affinity DataEC50:  4.5nMAssay Description:Tested in vitro against HIV-1 MDR using MAGI assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50597918(CHEMBL5206708)
Affinity DataEC50:  4.5nMAssay Description:Inhibition of wild type HIV-1 reverse transcriptase assessed as reduction in luciferase reporter activity by single-round assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50074597((S)-7-Allyl-5-chloro-8-methyl-6,7,8,9-tetrahydro-2...)
Affinity DataEC50:  4.60nMAssay Description:Effective concentration against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50094286(4-Amino-1-(5-ethynyl-4-hydroxy-5-hydroxymethyl-tet...)
Affinity DataEC50:  4.80nMAssay Description:Tested in vitro against HIV-1 LAI from MT-4 cells using MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50369747(CHEMBL607878)
Affinity DataEC50:  4.80nMAssay Description:Tested in vitro against HIV-1 LAI from MT-4 cells using MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50061697(6-(3,5-Dimethyl-phenylsulfanyl)-1-(2-hydroxy-ethox...)
Affinity DataEC50:  5nMAssay Description:Inhibitory concentration against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50123880((4-Chloro-phenyl)-(2-chloro-pyridine-4-carbonyl)-t...)
Affinity DataEC50:  5nMAssay Description:Concentration required to achieve 50% protection of MT-4 cell from the HIV-1 induced cytopathogenicity was determined by the MTT methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50369418(CHEMBL58711 | R-87027)
Affinity DataEC50:  5.10nMAssay Description:Effective concentration against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50407261(CHEMBL137575)
Affinity DataEC50:  5.15nMAssay Description:Effective concentration in vitro agaianst HIV-1-infected CEM cells relative to uninfected untreated controlsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50094282(2-Amino-9-(5-ethynyl-4-hydroxy-5-hydroxymethyl-tet...)
Affinity DataEC50:  5.40nMAssay Description:Tested in vitro against HIV-1 MDR using MAGI assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataEC50:  5.40nMAssay Description:Inhibition of HIV-1 p66/p51 reverse transcriptase Y181C mutant incubated for 40 mins by picogreen dye-based spectrofluorometric analysisMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50566509(CHEMBL4845938)
Affinity DataEC50:  5.40nMAssay Description:Inhibition of HIV-1 p66/p51 reverse transcriptase K103N mutant incubated for 40 mins by picogreen dye-based spectrofluorometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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